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This information is valuable for developing effective harm reduction strategies and to assess product abuse liability potential (defined by the FDA as the likelihood that individuals will develop physical and/or psychological dependence on the tobacco product )

The visible changes caused by smoking can therefore serve as an early warning sign of internal harm

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Researchers at Wake Forest took saliva samples and found that by the end of a season, non-smoking workers had nicotine levels equivalent to regular smokers. Nicotine has been associated with bladder cancer and has been found to increase the size of other tumors